News

Ayahuasca-induced personal death subjective experiences

Researchers analysed studies on self-reported experiences related to the sensation of death during ayahuasca ceremonies.

Could we have psi abilities if our brains didn't inhibit them?

Research tests a novel neurobiological model and concludes that the frontal lobes of the brain act as a filter to inhibit humans' innate psi abilities.

The impact of after-death communication in bereavement

A study with 70 participants who experienced after-death communication with deceased partners reveals that the majority found it comforting and helpful in their bereavement.

Can experienced meditators voluntarily turn off their consciousness?

A study reveals that experienced meditators are able to voluntarily modulate their state of consciousness during meditation.

What do we remember from a movie varies with age?

Researchers evaluated how young adults and middle-aged recall detailed information from a movie after one week.

Is gratitude good for the heart?

A study reveals that gratitude may buffer the negative physiological consequences of stress and overall improve cardiovascular outcomes.

People with more peace of mind are better at regulating emotions?

Research shows that people with higher levels of peace of mind are better at reinterpreting situations to regulate their emotions, rather than suppressing them.

Mother's stress during pregnancy can impact children’s sleep in childhood

Study shows that mothers' psychosocial stress during pregnancy has negative associations with their children's sleep that persist across childhood.

Do robots have to be human-like for us to trust them?

Recently published research assessed human trust when collaborating with eyed and non-eyed robots of the same type.

What do near-death experiences and psychedelic experiences have in common?

Researchers analysed the similarities and differences between a near-death experience and the experience induced by a psychedelic drug.

What interferes the most with our short-term memory?

Researchers performed experiments to explore the effects of changing-state vibrotactile sequences on short-term memory.

Can childhood trauma cause insomnia in adults?

Research has shown that adverse childhood experiences result in more dysfunctional ways of shame coping and increase the severity of insomnia in adulthood.

How does postingestive reward shape our choices?

Postingestive processes, which refer to the physiological and behavioural responses occurring after food intake, are crucial for regulating eating behaviour, influencing both the sensation of satiety and food preferences. The research team led by Albino Oliveira Maia investigated the impact of these processes on three distinct groups: healthy individuals, people with obesity, and post-bariatric surgery patients. Specifically, the study explored whether these effects occur through implicit (non-conscious) mechanisms and how the availability of dopamine D2 receptors in the brain is related to these processes. Using the flavour-nutrient conditioning (FNC) method, where the flavour of yogurt enriched with maltodextrin was associated with increased caloric content, it was observed that food preferences were influenced primarily through implicit consumption decisions rather than explicit assessments of flavour pleasantness ratings. In other words, the study demonstrated that FNC affected food choices without participants being consciously aware that they were preferring foods due to their association with nutritional value. This shift was observed in healthy individuals, people with obesity, and post-bariatric patients. Furthermore, people with obesity showed lower availability of dopamine D2 receptors, crucial in the brain's reward system. After bariatric surgery, particularly gastric bypass, there was an increase in receptor availability, which may be linked to improved feeding behavior regulation. These findings suggest that changes in the reward system may play a role in the surgery's effectiveness in reducing weight and modifying eating behaviours. This study was supported by the BIAL Foundation, in the scope of the research project 176/10 - Dopaminergic regulation of dietary learning in humans and rodents, and published in the journal PLOS BIOLOGY, in the article Postingestive reward acts through behavioral reinforcement and is conserved in obesity and after bariatric surgery.

Maria de Sousa Award 5th edition - 2025: applications are open

Applications are now open for the Maria de Sousa Award 5th edition - 2025, promoted by the Portuguese Medical Association and the BIAL Foundation to honour the physician and great researcher Maria de Sousa. The deadline for applications is 31 May.

The BIAL Foundation has received 432 applications for the Grants Programme for Scientific Research

Did you know that the BIAL Foundation received 432 applications from 29 countries for the Grants Programme for Scientific Research 2024/2025, and 80 were approved?

BIAL Award in Biomedicine 2025 increases value to 350,000 euros and opens nominations

The fourth edition of the BIAL Foundation international award, the BIAL Award in Biomedicine, is underway, with nominations open until 30 June. This edition, with an increase in value to 350,000 euros, seeks to recognise work published in the broad biomedical field within the last ten years, the results of which are considered of exceptional quality and scientific relevance.

Do placebos work even when we know they're placebos?

Research has shown that placebo-related expectations are linked to activation changes in regions involved in attention and cognitive control (e.g., anterior cingulate cortex), as well as somatosensory integration (insula and parietal regions). However, these studies have typically used deceptive placebos presented as active treatments. To date, the effects of non-deceptive placebos, or open-label placebos (OLPs), that is patients are fully aware that they are not taking an active medication, have not been fully explored. Anne Schienle and Albert Wabnegger conducted an fMRI study to examine the effects of open-label placebos on emotional regulation, specifically in reducing feelings of disgust. Participants rated the expected effect of the OLPs before the experiment and evaluated the perceived effect after the experiment. Results indicated that when participants’ expectations concerning the OLP treatment were met, there was reduced brain activity in key brain areas, including the anterior cingulate cortex, insula, parietal regions, as well as parahippocampus. These areas are crucial for identifying meaningful stimuli and for evaluating both the emotional relevance and context of an experience. Thus, the decrease in activity in these areas suggests that when expectations are met, the brain processes the emotional salience and context of the stimulus more efficiently and with less intensity, contributing to emotional regulation. This study, published in the journal Brain Research Bulletin, in the paper Neural correlates of expected and perceived treatment efficacy concerning open-label placebos for reducing emotional distress, was supported by the BIAL Foundation, in the scope of the research project 03/22 - The power of imagination: Neural effects of imagined placebo intake.

Does belief in the paranormal make us more vulnerable to stress?

The idea that belief in the paranormal is associated with maladaptive psychological processes has been widely challenged by recent studies. These studies suggest that, in the absence of specific predispositions, such as high levels of transliminality (an increased sensitivity to internal and external stimuli) and traits associated with psychopathology (such as schizotypy and manic-depressive tendencies), the belief in the paranormal does not compromise psychological adjustment or well-being. However, it remains an open question whether different types of paranormal belief, namely Traditional Paranormal Belief (TPB, linked to cultural and social notions of control by supernatural forces) and New Age Philosophy (NAP, associated with more individual and spiritual concerns), can lead to variations in the way they influence the perception of well-being and psychological adjustment. In the scope of project 123/20 - A latent profile analysis and structural equation modelling of paranormal belief, psychopathological symptoms, and well-being, supported by the BIAL Foundation and led by Neil Dagnall, the research team conducted a study exploring whether TPB and NAP are differentially associated with perceived stress (a variable often used in studies in the field as an indicator of well-being). The results indicated that TPB was significantly associated with higher levels of distress and a reduced capacity for coping. In contrast, NAP showed no predictive association. These findings suggest that TPB may reflect a reduced perception of control over external factors, increasing susceptibility to stress, whereas NAP, due to its focus on more individual concerns, does not appear to contribute to these dynamics. Thus, understanding the functional differences between these beliefs is essential to addressing the psychological impact of belief in the paranormal. This study was published in the journal PLOS ONE, in the article Re-evaluation of the relationship between paranormal belief and perceived stress using statistical modelling.

Nuno Grande Doctoral Scholarship 2024: applications are open

Applications are now open for the Nuno Grande Doctoral Scholarship 2024, worth €25,000. Candidates must, at the time of application submission, be enrolled in the Doctoral Program in Medical Sciences at the Abel Salazar Institute of Biomedical Sciences (ICBAS). The applications are open until January 17, 2025.

How do psychedelics influence social cognition?

Psychedelics have sparked interest as potential treatments for social cognition deficits commonly associated with the autism spectrum and social anxiety. Previous studies have shown that psychedelics modulate social processing by altering emotion recognition in facial expressions, joint attention in social interactions, perspective-taking, and empathy. The evidence suggests that the effect may be linked to their impact on social cognition networks. However, the exact mechanisms underlying this impact remain poorly understood. The research team led by Miguel Castelo-Branco conducted a pharmacological study investigating the effects of N,N-Dimethyltryptamine (psychedelic DMT) on functional connectivity in brain regions relevant to social cognition, using a within-subject design. The results supported the hypothesis that DMT induces changes in functional connectivity in brain regions relevant to social cognition, as well as in areas associated with emotion and affective value. Furthermore, changes in connectivity strength were correlated with increases in self-reported psychedelic effects. These correlations highlight the relationship between DMT’s neural effects on socioemotional circuits and subjective experiences. These findings offer insights into the effects of psychedelics on social behaviour, with implications for disorders like social anxiety and depression. Simultaneously, they suggest that increased connectivity, rather than reduced activity, plays a crucial role in psychedelic states. Thus, these results advance our understanding of the therapeutic potential of psychedelics and their effects on the "social brain". This study was supported by the BIAL Foundation, in the scope of the research project 252/18 - Spiritual states induced by ayahuasca, and the involvement of the reward system, and published in Frontiers in Pharmacology, in the article Increased functional connectivity between brain regions involved in social cognition, emotion and affective-value in psychedelic states induced by N,N-Dimethyltryptamine (DMT).

How does body size influence weight perception?

Currently, it is known that the size of an object influences how heavy it feels (i.e., the size-weight illusion). However, it remains uncertain whether the same applies to the body. Elisa Raffaella Ferrè and colleagues conducted an experimental study to investigate how embodying various hand sizes affects the perception of hand weight. Hand size was manipulated using a visual-tactile illusion with magnifying and minifying mirrors. The results showed that the perception of hand weight is flexible and easily altered by the perception of hand size. However, the perceived weight of the hand is invariably underestimated. Although a larger hand feels heavier, while a smaller hand feels lighter, there is still an underestimation of the actual weight of the hand in both conditions. This also contrasts with object perception, where larger objects feel lighter when compared to smaller objects of the same weight. Given that individuals with anorexia nervosa, for example, often experience their bodies as objects, these findings may help deepen our understanding of such disorders and their connection to bodily distortions. This study was supported by the BIAL Foundation, in the scope of the research project 41/20 - Luminous dancing fairies in weightlessness: How gravity shapes conscious experiences, and published in the journal Cognition, in the article Perceived hand size and perceived hand weight.

Award Universidade de Lisboa|Fundação BIAL 30 Years honours Medicine, Psychology and Philosophy students

Academic competition in António Damásio and Hanna Damásio lecture aims to stimulate students' capacity for reflection, interpretation, and critical analysis.

Prof. Peter Fenwick

The BIAL Foundation expresses profound sorrow on the passing of Prof Peter Fenwick, a unique figure in parapsychology worldwide, broadly awarded for his work on the process of death, including consciousness and near-death experiences.

Can psychedelics enhance meditative training?

While the therapeutic evidence for meditation and psychedelics has been established as standalone interventions, recent research has started to point potential synergies in combining them. The research team led by Milan Scheidegger conducted a randomized placebo-controlled study aiming to test whether N,N-dimethyltryptamine (DMT), an active ingredient of ayahuasca, and harmine (DMT-harmine) combined with meditation increases (1) mindfulness, (2) compassion, (3) insight, and (4) mystical-type transcendence to a larger degree than meditation with a placebo during a 3-day mindfulness retreat. Findings showed that mindfulness and compassion were not significantly different in the DMT-harmine group compared to placebo. However, the DMT-harmine group self-attributed greater levels of mystical-type experiences, non-dual awareness, and emotional breakthrough during the acute substance effects compared to meditation with a placebo. It seems that DMT-harmine may support meditation and meditation-related well-being through eliciting experiences of insight, transcendence, and meaning rather than through mindfulness or compassion. This study was supported by the BIAL Foundation, in the scope of the research project 333/20 - Mindfulness and psychedelics: A neurophenomenological approach to the characterization of acute and sustained response to DMT in experienced meditators, and published in the Journal of Psychopharmacology, in the article Meditating on psychedelics. A randomized placebo-controlled study of DMT and harmine in a mindfulness retreat.

The quest of physiological markers for the experience of pain

Researcher: Elia Valentini - Department of Psychology & Centre for Brain Science, University of Essex Summary: The aim of this project is to improve measurement of the human experience of pain by investigating a combination of psychophysical and physiological responses during mild noxious stimulation. More specifically, we want to investigate how sensitive and specific to pain the brain oscillatory responses are. We use EEG as the main technique, but we are keen to collaborate with neuroscientists using fMRI, autonomic measures and brain stimulation as well as with computational neuroscientists. A clinical collaborator would also be very much welcome.

EEG investigation of hypnosis and decision-making

Researcher: Rinaldo Livio Perri - University Niccolò Cusano Rome, Italy Summary: I work in the field of hypnosis and cognitive neuroscience. In particular, I adopt the event-related potentials (ERPs) to investigate the effect of the hypnotic suggestions on sensory processing and cognitive performance. I am an expert in decision-making and proactive brain processes before the stimulus administration (e.g., the perceptual, prefrontal and premotor readiness during the expectancy stage). I could help colleagues to properly analyze the ERP signal in the pre-stimulus stage of processing. Also, I would be happy to share my EEG data for re-analyzing them in the frequency domain (e.g., wavelet or coherence analysis in the hypnosis research). Feel free to contact me for any question! More information on my papers: https://scholar.google.it/citations?user=-8e_V64AAAAJ&hl=it Possible collaborations: neuroscientist with experience in the EEG frequency analysis Email: perri.rinaldo@gmail.com

Transparent Psi Project - looking for collaborators

Summary: We are running a fully transparent, expert consensus-base multilab replication of Bem’s (2011) experiment 1. The project features state of the art methods to maximize transparency and study integrity. The study involves a computerized experiment taking about 20 minutes per session. Group testing is possible in a computer lab, no specialized equipment needed. Labs are expected to recruit at least 100 participants. Participants will be exposed to images with explicit erotic/sexual content in the experiment. No financial compensation is required for the participants. Data collection is expected to take place in the 2020 fall semester. Every material is provided for ethics/IRB submissions and data collection in English (translation of materials might be necessary by the collaborators). The study is pre-registered and the manuscript is accepted in principle for publication in the journal Royal Society Open Science. All collaborators who meet the minimum sample size criterion will get authorship on this paper reporting the results of the replication study. More information in the preprint: https://psyarxiv.com/uwk7y/ Indicate interest in the collaboration via the following form: https://tinyurl.com/tpp-labs With any question contact the lead investigator: Dr. Zoltan Kekecs, kekecs.zoltan@gmail.com

Cognitive control and learning

Researcher: Ignacio Obeso, Ph.D. / CINAC - HM Puerta del Sur Summary: The aim of our projects is to understand the behavioral and neural mechanisms used to learn how humans establish adaptive behaviour in changing contexts. More specifically, we want to decipher how stopping abilities are initially learned and later executed under automatic control. We use task-related fMRI, brain stimulation and clinical models to test our predictions in laboratory settings as well as online home-based paradigms. Possible collaborations: computational scientist Email contact: i.obesomartin@gmail.com https://iobesomartin.wixsite.com/cognitivecontrol